Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity
Background Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell acute lymphoblastic leukemia Production Accessories (B-ALL), relapse is common.Bone marrow (BM) mesenchymal stem/stromal cells (BM-MSC) are key components of the hematopoi